| Date | Time | At | Opponent | Location | TV | Result |
| Sep 1 (Mon) | 8:00 PM | Home | TCU | Chapel Hill, N.C. (Kenan Stadium) | ESPN | L 14-48 |
| Sep 6 (Sat) | 7:00 PM | Away | Charlotte | Charlotte, N.C. (Jerry Richardson Stadium) | ESPN+ | W 20-3 |
| Sep 13 (Sat) | 3:30 PM | Home | Richmond | Chapel Hill, N.C. (Kenan Stadium) | ACCN | W 41-6 |
| Sep 20 (Sat) | 3:30 PM | Away | UCF | Orlando, Fla. (Acrisure Bounce House) | FOX | L 9-34 |
| Oct 4 (Sat) | Noon | Home | Clemson | Chapel Hill, N.C. (Kenan Stadium) | ESPN | L 10-38 |
| Oct 17 (Fri) | 10:30 PM | Away | California | Berkeley, Calif. (California Memorial Stadium) | ESPN | L 18-21 |
| Oct 25 (Sat) | Noon | Home | #16 Virginia | Chapel Hill, N.C. (Kenan Stadium) | ACCN | L 16-17 |
| Oct 31 (Fri) | 7:30 PM | Away | Syracuse | Syracuse, N.Y. (JMA Wireless Dome) | ESPN | W 27-10 |
| Nov 8 (Sat) | 4:30 P.M. | Home | Stanford | Chapel Hill, N.C. (Kenan Stadium) | The CW | W 20-15 |
| Nov 15 (Sat) | 4:30 P.M. | Away | Wake Forest | Winston-Salem, N.C. (Allegory Federal Credit Union Stadium) | The CW | L 28-12 |
| Nov 22 (Sat) | 3:30 PM | Home | Duke | Chapel Hill, N.C. (Kenan Stadium) | ACCN | L 32-25 |
| Nov 29 (Sat) | 7:30 PM | Away | NC State | Raleigh, N.C. (Carter-Finley Stadium) | ACCN | L 42-19 |