| Date | Time | At | Opponent | Location | Result |
| November 25, 2020 (Wednesday) | 6:00 PM | Home | College of Charleston | Chapel Hill | W, 79-60 |
| November 30, 2020 (Monday) | 7:00 PM | UNLV | Asheville, N.C. Maui Invitational | W, 78-51 | |
| December 1, 2020 (Tuesday) | 4:00 PM | Stanford | Asheville, N.C. Maui Invitational | W, 67-63 | |
| December 2, 2020 (Wednesday) | 4:00 PM | Texas | Asheville, N.C. Maui Invitational | L, 67-69 | |
| December 8, 2020 (Tuesday) | 7:30 PM | Away | Iowa | Iowa City, Iowa ACC/Big Ten Challenge | L, 80-93 |
| December 12, 2020 (Saturday) | 2:00 PM | Home | North Carolina Central | Chapel Hill | W, 73-67 |
| December 19, 2020 (Saturday) | 2:00 PM | Kentucky | Cleveland, Ohio CBS Sports Classic | W, 75-63 | |
| December 22, 2020 (Tuesday) | 7:00 PM | Away | North Carolina State | Raleigh, N.C. | L, 76-79 |
| December 30, 2020 (Wednesday) | 8:00 PM | Away | Georgia Tech | Atlanta, Ga. | L, 67-72 |
| January 2, 2021 (Saturday) | 4:00 PM | Home | Notre Dame | Chapel Hill | W, 66-65 |
| January 5, 2021 (Tuesday) | 8:00 PM | Away | Miami | Coral Gables, Fla. | W, 67-65 |
| January 9, 2021 (Saturday) | 7:00 PM | Home | Clemson | Chapel Hill | Postponed |
| January 12, 2021 (Tuesday) | 9:00 PM | Home | Syracuse | Chapel Hill | W, 81-75 |
| January 16, 2021 (Saturday) | Noon | Away | Florida State | Tallahassee, Fla. | L, 75-82 |
| January 20, 2021 (Wednesday) | 7:00 PM | Home | Wake Forest | Chapel Hill | W, 80-73 |
| January 23, 2021 (Saturday) | 2:00 PM | Home | North Carolina State | Chapel Hill | W, 86-76 |
| January 26, 2021 (Tuesday) | 7:00 PM | Away | Pittsburgh | Pittsburgh, Pa. | W, 75-65 |
| February 2, 2021 (Tuesday) | 7:00 PM | Away | Clemson | Clemson, S.C. | L, 50-63 |
| February 6, 2021 (Saturday) | 6:00 PM | Away | Duke | Durham, N.C. | W, 91-87 |
| February 8, 2021 (Monday) | 7:00 PM | Home | Miami | Chapel Hill | Postponed |
| February 13, 2021 (Saturday) | 6:00 PM | Away | Virginia | Charlottesville, Va. | L, 48-60 |
| February 16, 2021 (Tuesday) | 7:00 PM | Home | Virginia Tech | Chapel Hill | Postponed |
| February 17, 2021 (Wednesday) | 7:00 PM | Home | Northeastern | Chapel Hill | W, 82-62 |
| February 20, 2021 (Saturday) | 6:00 PM | Home | Louisville | Chapel Hill | W, 99-54 |
| February 23, 2021 (Tuesday) | 9:00 PM | Away | Boston College | Chestnut Hill, Mass. | Postponed |
| February 24, 2021 (Wednesday) | 7:00 PM | Home | Marquette | Chapel Hill | L, 70-83 |
| February 27, 2021 (Saturday) | 4:00 PM | Home | Florida State | Chapel Hill | W, 78-70 |
| March 1, 2021 (Monday) | 7:00 PM | Away | Syracuse | Syracuse, N.Y. | L, 70-72 |
| March 6, 2021 (Saturday) | 6:00 PM | Home | Duke | Chapel Hill | W, 91-73 |
| March 9, 2021 (Tuesday) | TBA | ACC Tournament First Round | Greensboro, N.C. | N/A | |
| March 10, 2021 (Wednesday) | 9:00 PM | ACC Tournament | Notre Dame | Greensboro, N.C. | W, 101-59 |
| March 11, 2021 (Thursday) | 8:30 PM | ACC Tournament | Va. Tech | Greensboro, N.C. | W, 81-73 |
| March 12, 2021 (Friday) | 8:30 PM | ACC Tournament | Florida St. | Greensboro, N.C. | L, 69-66 |
| March 13, 2021 (Saturday) | TBA | ACC Tournament Final | Greensboro, N.C. | ||
| March 19, 2021 (Friday) | 7:10 PM | NCAA Tournament | Wisconsin | Indianapolis, IN | L, 85-62 |
| March 21, 2021 (Sunday) | TBA | NCAA Tournament | Baylor | Indianapolis, IN | |
| March 26, 2021 (Friday) | TBA | NCAA Tournament | TBA | Indianapolis, IN | |
| March 28, 2021 (Sunday) | TBA | NCAA Tournament | TBA | Indianapolis, IN | |
| April 3, 2021 (Saturday) | TBA | NCAA Tournament | TBA | Indianapolis, IN | |
| April 5, 2021 (Monday) | TBA | NCAA Tournament | TBA | Indianapolis, IN |